As a doctor of anatomic pathology at the Pathology Laboratory of the Faculty of Medicine, University of Hasanuddin and Dr. Wahidin Sudirohusodo Hospital, Makassar, Upik Anderiani Miskad face many cases of colorectal cancer. Upik interested in finding ways to detect gene and protein phosphatase of regenerating liver-3 (PRL-3) as a marker in colorectal carcinoma metastasis and prognostic factors of the patient's blood.
Her research may someday help doctors determine the most appropriate method of treatment for the third leading cancer worldwide and the number two cause of death due to cancer. "Among the many in Indonesia gastrointestinal cancer, colorectal cancer ranks first and ranks fifth of all existing malignant disease," said Upik, who also practice at the Clinic and the Laboratory of Cytopathology Grand Medika, Makassar.
Cause of death in colorectal carcinoma is the occurrence of metastasis, or spread of cancer cells to other organs, such as lung and liver. In the process, the role of PRL-3 protein is very large in helping cancer cells metastasize. PRL-3 is a family of protein tyrosine phosphatase.
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| Colon Cancer. (Picture from: KORAN TEMPO 3689) |
"I try to detect PRL-3 on blood samples and compared with tissue samples," she said. "If the PRL-3, which is a marker of metastasis, can be detected in the blood, this information will be very useful in determining the handling steps, therapy or surgery."
If the presence of proteins that have been detected since early in colorectal cancer patients who have entered the process of metastasis, surgery can be avoided. "Often times the only known metastases at the time of surgery. In fact, when it spreads, it would be difficult to do the removal of the tumor," she said. "I hope the detection of PRL-3 in the blood can know through the development of cancer without having surgery."
In the future, PRL-3 as an oncoprotein (cells that cause normal cells to transform into cancer cells) can also serve as a promising therapeutic target. "Information and the levels of PRL-3 expression in colorectal cancer can be a basis for determining the therapeutic strategy of colorectal cancer, especially to people who already exist in the early detection of metastasis," said the lecturer and researcher from the Faculty of Medicine, University of Hasanuddin, "what is feasible or not to surgery or therapy enough, "
Busy life as a lecturer and physician pathology anatomy did not prevent the mother of two children were doing research. "We have to keep doing research," said this doctoral pathology of Kobe University, Japan.
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Doctors anatomic pathology Upik Anderiani Miskad winner L'Oreal-UNESCO for Women in Science 2011 Life Sciences category. (Picture from: KORAN TEMPO 3689)
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Diligence researching cancer make it the eldest of eight children was selected as one of three winners of the L'Oreal-UNESCO for Women in Science 2011 Life Sciences category.
As a female researcher, her role as mother remains undisturbed. Upik have always seeking quality time with her two children. "Quantity is clearly not, because since the morning I have been teaching in various places, even outside the region," said the woman was born Soppeng. *** [TJANDRA DEWI | KORAN TEMPO 3689]
Adverse Effects of Food on Intestinal
Upik Anderiani Miskad did not examine the effects of bad diet Makassar people who consume more meat and less fiber. But her hunch that dishes such as soto saudara, coto Makassar or effect on the higher incidence of colorectal cancer is true.
A study in Boston, United States, find a diet is likely associated with an increased risk of colorectal cancer in women. Researchers from Simmons College in Boston found a specific eating pattern associated with the level of concentration of C-peptide, a protein that increases women's risk of colorectal cancer.
"The high intake of red meat, fish, and sweet drinks, but the low coffee, grains, and dairy products high in fat, as a whole seems to be associated with high levels of C-peptide in the blood," said Teresa T. Fung, professor of nutrition at Simmons Coilege in Boston. The data presented at AACR international conference on cancer prevention research in the 22 to 25 October 2011.
C-peptide is a marker of insulin secretion can be measured in the blood. High levels are likely triggering insuiin growth and multiplication of cells. One of the main characteristics of cancer is abnormal cell growth. High levels of C-peptide and insulin trigger cancer cell growth.
"Colon cancer appears to be one type of cancer that are sensitive to insulin," said Fung. "This research gives a more complete picture of what happened on the mechanism and the relationship between diet and colorectal cancer risk."
As a female researcher, her role as mother remains undisturbed. Upik have always seeking quality time with her two children. "Quantity is clearly not, because since the morning I have been teaching in various places, even outside the region," said the woman was born Soppeng. *** [TJANDRA DEWI | KORAN TEMPO 3689]
Upik Anderiani Miskad did not examine the effects of bad diet Makassar people who consume more meat and less fiber. But her hunch that dishes such as soto saudara, coto Makassar or effect on the higher incidence of colorectal cancer is true.
A study in Boston, United States, find a diet is likely associated with an increased risk of colorectal cancer in women. Researchers from Simmons College in Boston found a specific eating pattern associated with the level of concentration of C-peptide, a protein that increases women's risk of colorectal cancer.
"The high intake of red meat, fish, and sweet drinks, but the low coffee, grains, and dairy products high in fat, as a whole seems to be associated with high levels of C-peptide in the blood," said Teresa T. Fung, professor of nutrition at Simmons Coilege in Boston. The data presented at AACR international conference on cancer prevention research in the 22 to 25 October 2011.
C-peptide is a marker of insulin secretion can be measured in the blood. High levels are likely triggering insuiin growth and multiplication of cells. One of the main characteristics of cancer is abnormal cell growth. High levels of C-peptide and insulin trigger cancer cell growth.
"Colon cancer appears to be one type of cancer that are sensitive to insulin," said Fung. "This research gives a more complete picture of what happened on the mechanism and the relationship between diet and colorectal cancer risk."
Fung and his team conducted a survey of a number of women every two years to determine their general health information, including whether they were diagnosed with colorectal cancer. They also examine their eating habits with a questionnaire containing 130 types of food and asked how often they consume these foods.
After 22 years later, there were 985 cases of colorectal cancer and 758 cases of colon cancer diagnosed among the women. Penellti found most often women who ate red meat, fish, and drinks mahis in large numbers, but mengasup coffee, grains, and high-fat dairy products in small quantities, has a 35 percent risk of colorectal cancer.
Researchers also compared the information women slender and active with women who are overweight and rarely exercise. "We find people who are overweight or inactive are more sensitive to diet," said Fung. "The risk of colorectal cancer are higher than those who are slim and active." *** [SCIENCEDAILY | AACR | KORAN TEMPO 3689]
