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Friday, August 12, 2011

Why Are There People Who Do Not Have Fingerprints?

A rare gene mutation may be the cause of why some people are born without fingerprints. The scientific name for the disease is adermatoglyphia, because the scientists call a small curved lines on our fingers and toes as dermatoglyph. In most people, the fingerprint is formed when the fetus in the womb, 24 weeks before birth. But at least four families in the world born without fingerprints. Side effects of this disorder is blistered skin and facial cysts. This rare disease known in 2007, when a young woman trying to cross borders Swiss nationality United States. Immigration officials could not confirm the identity of the woman. Otherwise suitable passport photo with her face, but when her finger is attached to a scanner, a fingerprint can not be found. Dermatology expert from Tel Aviv Sourasky Medical Center in Israel tested the woman's family and found nine family members also do not have fingerprints. Eli Sprecher and his team from the medical center was suspected genetic abnormality that caused the problem. They collect data and compare the DNA of family members with a normal family of DNA data. This comparison is then sequenced genomes to look for the cause of abnormalities. "Initially we did not find anomalies when comparing the DNA of this," says Sprecher. But a student named Janna Nousbeck see a brief sequence that overlaps with a gene named SMARCAD1. From this point mutation causes an estimated loss of the fingerprint originate. "The mutation itself did not occur in the gene that encodes a protein SMARCAD1, but close to the location of the connection that encodes SMARCAD1 perfectly," says Sprecher. Sprecher next research is figuring out the function of genes SMARCAD1 to the formation of the fingerprint pattern. But he has a strong probability that these genes helps the cell folding during fetal development.*** [SCIENCEMAG | LIVESCIENCE | ANTON WILLIAM | TEMPO 3615]
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