Puzzle why some people have apple-shaped body, large at the top and slim at the bottom, and a pear, a little at the top and enlarged at the hip, now began to lift. Scientists at the University of Edinburgh, UK, found a protein that plays a role in regulating how fat is stored in the body.
Recent findings that provide a greater understanding of how proteins work, which can help the development of drugs to tackle obesity. Levels of proteins known as 11BetaHSD1 tended to be higher on the kind of unhealthy body fat that tends to be stored around the waist, typical apple shape.
Healthier fats, proteins associated with lower levels, tend to be stored around the hips and used more safely by the body as an energy source, a hallmark of people who have a pear shape.
The study found that mice with 11BetaHSD1 proteins in the body tend to have unhealthy fat tissue after four weeks were given high-fat diet, compared to mice lacking the protein.
Scientists are now looking for ways to dispensing drugs that can block the work of this protein, which is known to raise levels of hormones associated with obesity. "This study opens the way for research, and gives a better idea why no body fat to be unhealthy, while others remain safely stored fat for energy," said Dr Nik Morton, of the Centre for Cardiovascular Science at the University of Edinburgh. "Inflammation of unhealthy fats trigger a reaction that can cause harm to the network and affect the organism, causing diabetes. Limiting these proteins help fight the disease."
Besides tend stored around vital organs in the torso, fat with 11BetaHSD1 higher levels considered unhealthy when associated with an overreaction in the immune system.
*** [SCIENCEDAILY | KORAN TEMPO 3478]
Puzzle why some people have apple-shaped body, large at the top and slim at the bottom, and a pear, a little at the top and enlarged at the hip, now began to lift. Scientists at the University of Edinburgh, UK, found a protein that plays a role in regulating how fat is stored in the body.
Recent findings that provide a greater understanding of how proteins work, which can help the development of drugs to tackle obesity. Levels of proteins known as 11BetaHSD1 tended to be higher on the kind of unhealthy body fat that tends to be stored around the waist, typical apple shape.
Healthier fats, proteins associated with lower levels, tend to be stored around the hips and used more safely by the body as an energy source, a hallmark of people who have a pear shape.
The study found that mice with 11BetaHSD1 proteins in the body tend to have unhealthy fat tissue after four weeks were given high-fat diet, compared to mice lacking the protein.
Scientists are now looking for ways to dispensing drugs that can block the work of this protein, which is known to raise levels of hormones associated with obesity. "This study opens the way for research, and gives a better idea why no body fat to be unhealthy, while others remain safely stored fat for energy," said Dr Nik Morton, of the Centre for Cardiovascular Science at the University of Edinburgh. "Inflammation of unhealthy fats trigger a reaction that can cause harm to the network and affect the organism, causing diabetes. Limiting these proteins help fight the disease."
Besides tend stored around vital organs in the torso, fat with 11BetaHSD1 higher levels considered unhealthy when associated with an overreaction in the immune system. *** [SCIENCEDAILY | KORAN TEMPO 3478]
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